- mom-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; asymmetric protein localization involved in cell fate determination; and embryonic morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Is an ortholog of human PORCN (porcupine O-acyltransferase).
- mom-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables receptor tyrosine kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; embryonic morphogenesis; and neuron migration. Predicted to be located in extracellular space. Expressed in several structures, including HSN; P5.ppp; P7.paa; anchor cell; and epithelial cell.
- tap-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mitogen-activated protein kinase kinase kinase binding activity and protein kinase activator activity. Involved in endodermal cell fate specification and negative regulation of Ras protein signal transduction. Predicted to be located in cytosol and nucleus. Expressed in cholinergic neurons; coelomocyte; and somatic neurons. Is an ortholog of human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1).
- mom-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including embryonic morphogenesis; neuron migration; and regulation of locomotion. Predicted to be located in plasma membrane. Expressed in several structures, including QL.a; anus; gonad; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; nonsyndromic congenital nail disorder 1; and omodysplasia 2. Is an ortholog of human FZD1 (frizzled class receptor 1); FZD2 (frizzled class receptor 2); and FZD7 (frizzled class receptor 7).
- mom-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables MAP kinase kinase kinase activity. Involved in several processes, including cell fate commitment; embryonic digestive tract morphogenesis; and signal transduction. Located in striated muscle dense body. Expressed in BAGL and BAGR. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); frontometaphyseal dysplasia 2; and intrinsic cardiomyopathy (multiple). Is an ortholog of human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).
- gld-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables poly(A) RNA polymerase activity. Involved in mRNA polyadenylation. Located in P granule. Part of polysome. Expressed in Z2; Z3; and germ line. Is an ortholog of human TENT4A (terminal nucleotidyltransferase 4A) and TENT4B (terminal nucleotidyltransferase 4B).
- mig-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable frizzled binding activity. Involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway. Located in cell cortex. Expressed in several structures, including distal tip cell; linker cell; nerve ring; posterior lateral left ganglion; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; Robinow syndrome (multiple); and lung cancer. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1); DVL2 (dishevelled segment polarity protein 2); and DVL3 (dishevelled segment polarity protein 3).
- apr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2).
- plr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway. Located in Golgi apparatus; early endosome; and late endosome. Expressed in several structures, including egg-laying apparatus; enteric muscle; neurons; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); irritable bowel syndrome; and villous adenoma. Is an ortholog of human RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3).
- lit-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables beta-catenin binding activity and protein serine/threonine kinase activity. Involved in several processes, including cell fate commitment; polarity specification of proximal/distal axis; and positive regulation of nematode male tail tip morphogenesis. Located in cell cortex and nucleus. Part of serine/threonine protein kinase complex. Expressed in several structures, including hermaphrodite gonad; pharynx; tail hypodermis; and vulva. Is an ortholog of human NLK (nemo like kinase).