This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in primary miRNA processing and regulation of developmental process. Predicted to be part of microprocessor complex. Expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Is an ortholog of human DGCR8 (DGCR8 microprocessor complex subunit).
Predicted to be involved in primary miRNA processing. Predicted to be located in nuclear body. Is an ortholog of human SRRT (serrate, RNA effector molecule).
Enables 5'-3' RNA exonuclease activity. Involved in several processes, including miRNA catabolic process; negative regulation of miRNA-mediated gene silencing; and regulation of vulval development. Located in nucleus. Expressed in M5 neuron; PVT; intestine; and pharyngeal epithelial cell. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; leiomyosarcoma; and lung cancer. Is an ortholog of human XRN2 (5'-3' exoribonuclease 2).
Predicted to enable mRNA binding activity. Predicted to be involved in miRNA processing. Predicted to be located in nucleus. Is an ortholog of human SNIP1 (Smad nuclear interacting protein 1).
Enables ribonuclease III activity. Involved in primary miRNA processing and sexual reproduction. Predicted to be located in nucleus. Predicted to be part of microprocessor complex. Is an ortholog of human DROSHA (drosha ribonuclease III).