lin-28

Caenorhabditis elegans

Enables RNA binding activity and enzyme binding activity. Involved in several processes, including regulation of cell fate specification; regulation of development, heterochronic; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in germ line; hypodermis; muscle cell; nervous system; and neurons. Is an ortholog of human LIN28A (lin-28 homolog A) and LIN28B (lin-28 homolog B).

F02D10.10

Caenorhabditis elegans

Is affected by lin-28; hmg-3; and daf-2 based on RNA-seq and microarray studies.

C10G11.6

Caenorhabditis elegans

Enriched in germ line and germline precursor cell based on RNA-seq studies. Is affected by several genes including hsf-1; pgl-1; and lin-28 based on microarray and RNA-seq studies. Is affected by seven chemicals including rotenone; Aspirin; and Alovudine based on RNA-seq studies.

M03C11.3

Caenorhabditis elegans

Enriched in AVK and germ line based on RNA-seq studies. Is affected by several genes including isp-1; lin-28; and alg-1 based on microarray; RNA-seq; and proteomic studies. Is affected by four chemicals including rotenone; Zidovudine; and resveratrol based on RNA-seq and microarray studies.

Y50D7A.1

Caenorhabditis elegans

Enriched in OLL and PVD based on microarray studies. Is affected by several genes including sir-2.1; aak-2; and lin-28 based on RNA-seq and microarray studies. Is affected by six chemicals including rotenone; Psoralens; and allantoin based on RNA-seq and microarray studies. Is an ortholog of human FBXO42 (F-box protein 42).

T05B9.2

Caenorhabditis elegans

Enriched in neurons based on microarray and RNA-seq studies. Is affected by several genes including daf-2; lin-35; and lin-28 based on tiling array; RNA-seq; and microarray studies. Is affected by seven chemicals including metformin; Sirolimus; and Psoralens based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: PAN domain and PAN/Apple domain.

bath-34

Caenorhabditis elegans

Enriched in AVK; germ line; and germline precursor cell based on RNA-seq studies. Is affected by several genes including sir-2.1; pgl-1; and lin-28 based on microarray and RNA-seq studies. Is affected by eleven chemicals including D-glucose; stavudine; and Zidovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: BTB/POZ domain; BTB/POZ domain; MATH/TRAF domain; and SKP1/BTB/POZ domain superfamily.

lin-46

Caenorhabditis elegans

Predicted to enable molecular adaptor activity and molybdopterin molybdotransferase activity. Involved in regulation of development, heterochronic. Located in cytoplasm and nucleus. Expressed in hypodermis and seam cell. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type C. Is an ortholog of human GPHN (gephyrin).

K11D2.4

Caenorhabditis elegans

Enriched in several structures, including AVE; NSM; germ line; germline precursor cell; and head mesodermal cell based on tiling array and RNA-seq studies. Is affected by several genes including daf-2; hsf-1; and lin-28 based on RNA-seq and microarray studies. Is affected by ten chemicals including Tunicamycin; manganese chloride; and Psoralens based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Zinc finger, C2H2 type; Zinc finger C2H2-type; and Zinc finger C2H2 superfamily. Is an ortholog of human ZNF398 (zinc finger protein 398).

lin-4

Caenorhabditis elegans

Enables mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation of gene expression; oviposition; and positive regulation of vulval development. Part of polysome. Expressed in several structures, including P5.p hermaphrodite; P7.p hermaphrodite; gonad; neurons; and ventral nerve cord.