syg-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cell adhesion molecule binding activity. Involved in actin filament bundle assembly; cell-cell signaling; and nervous system development. Located in axon and synapse. Expressed in amphid sheath cell; egg-laying apparatus; head muscle; hypodermis; and neurons. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Is an ortholog of human KIRREL1 (kirre like nephrin family adhesion molecule 1) and KIRREL2 (kirre like nephrin family adhesion molecule 2).