Predicted to enable cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Located in endoplasmic reticulum membrane and protein-containing complex. Expressed in gonad. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18 and hereditary spastic paraplegia 62. Is an ortholog of human ERLIN1 (ER lipid raft associated 1) and ERLIN2 (ER lipid raft associated 2).
Enables UDP-N-acetylglucosamine 4-epimerase activity and UDP-glucose 4-epimerase activity. Involved in several processes, including gonad morphogenesis; negative regulation of endoplasmic reticulum unfolded protein response; and positive regulation of vulval development. Predicted to be located in cytosol. Expressed in head. Used to study galactosemia. Human ortholog(s) of this gene implicated in galactose epimerase deficiency. Is an ortholog of human GALE (UDP-galactose-4-epimerase).
Predicted to enable chitin synthase activity. Involved in cell wall chitin biosynthetic process; eggshell formation; and positive regulation of protein localization to cell cortex. Located in cell cortex and plasma membrane. Expressed in Psub1.
Enables calcium ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and hemidesmosome assembly. Located in cytoplasm. Expressed in several structures, including coelomocyte; excretory system; intestine; pharynx; and sperm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human CALR (calreticulin).
Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; multicellular organism reproduction; and system process. Located in endoplasmic reticulum and membrane. Expressed in several structures, including egg-laying apparatus; ganglia; gonad; non-striated muscle; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Gillespie syndrome; and isolated anhidrosis with normal sweat glands. Is an ortholog of human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in defecation and rhythmic behavior. Predicted to be located in dendritic spine; postsynaptic density; and postsynaptic membrane. Expressed in several structures, including amphid neurons; egg-laying apparatus; pharyngeal-intestinal valve; somatic nervous system; and sperm. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome; autistic disorder; and schizophrenia 15. Is an ortholog of human SHANK1 (SH3 and multiple ankyrin repeat domains 1).
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Expressed in body wall musculature; coelomocyte; reproductive tract; and in male.
Enables Hsp70 protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Involved in several processes, including determination of adult lifespan; egg-laying behavior; and protein ubiquitination. Located in cytoplasm. Expressed in several structures, including copulatory spicule; germ line; hermaphrodite distal tip cell; intestine; and pharynx. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Is an ortholog of human STUB1 (STIP1 homology and U-box containing protein 1).