- ins-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in maintenance of dauer; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Expressed in several structures, including coelomocyte; gonad; head muscle; nerve ring; and neurons.
- Gipc1 [Search on AGR]
Homo sapiens GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
- ins-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable hormone activity. Involved in olfactory learning. Predicted to be located in extracellular region and membrane. Expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system.
- Irs1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for targeted null mutations exhibit 50 percent reductions in body weights at birth and at 4 months of age, impaired glucose tolerance, and mild insulin and IGF-1 resistance. [provided by MGI curators]
- Kdm3b [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele show partial postnatal lethality, stunted postnatal growth, reduced serum IGF-1 and estradiol levels, prolonged estrous cycles, decreased ovulation rate and fertilization frequency, abnormal decidualization and embryo implantation, and female infertility. [provided by MGI curators]
- Ncoa3 [Search on AGR]
Mus musculus PHENOTYPE: Nullizygous mice exhibit growth defects and reduced serum IGF-1 levels and may show impaired proliferative responses to various factors, delayed mammary gland growth and puberty, reproductive dysfunction, susceptibility to endotoxin shock, altered lymphopoiesis, and protection against obesity. [provided by MGI curators]
- Arhgap5 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes die at birth, are 30% smaller, do not inflate their lungs, and show a small thymus, abnormal adipocyte differentiation and brain defects in the corpus callosum, anterior commissure and lateral ventricles. Mutant MEFs show impaired adipogenesis but undergo myogenesis in response to IGF-1. [provided by MGI curators]
- Agpat1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele show postnatal and premature death, reduced body weight and total body fat, decreased plasma leptin, glucose and IGF-1 levels, reduced gluconeogenesis, infertility, arrest of male meiosis, ovulation and estrous cycle anomalies, hyperactivity and audiogenic seizures. [provided by MGI curators]
- sip-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable unfolded protein binding activity. Involved in several processes, including determination of adult lifespan; embryo development; and response to heat. Located in cytosol. Expressed in body wall musculature and gonad.