Predicted to enable mRNA binding activity. Located in nucleus. Expressed widely. Is an ortholog of human HNRNPR (heterogeneous nuclear ribonucleoprotein R) and SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein).
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Predicted to enable mRNA 3'-UTR binding activity. Involved in hemidesmosome assembly. Located in chromosome, telomeric region. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; amyotrophic lateral sclerosis type 20; carcinoma (multiple); and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Is an ortholog of human HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) and HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3).