Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction; distal dendrite; and plasma membrane. Part of catenin complex. Expressed in several structures, including germline precursor cell; hypodermis; motor neurons; nerve ring; and neuroblasts.
Enables several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and left/right axis specification. Located in adherens junction and nucleus. Part of catenin complex. Expressed in distal tip cell and germ cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; gastrointestinal system cancer (multiple); germ cell cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human JUP (junction plakoglobin).
Predicted to enable cell adhesion molecule binding activity. Involved in actin filament organization; embryo development; and embryonic morphogenesis. Located in adherens junction and bicellular tight junction. Human ortholog(s) of this gene implicated in biliary tract cancer (multiple); disease of metabolism; and progressive familial intrahepatic cholestasis 4. Is an ortholog of human TJP2 (tight junction protein 2).
Involved in cell-cell adhesion; defense response to Gram-negative bacterium; and innate immune response. Located in cell junction. Expressed in epithelial cell; hypodermis; and nerve ring. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Is an ortholog of human TMEM47 (transmembrane protein 47).
Enables cadherin binding activity. Involved in embryonic body morphogenesis; regulation of actin cytoskeleton organization; and regulation of protein localization. Located in adherens junction. Part of catenin complex. Expressed in head. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; blepharocheilodontic syndrome 2; and oral squamous cell carcinoma. Is an ortholog of human ARVCF (ARVCF delta catenin family member).