Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in intracellular zinc ion homeostasis and zinc ion transmembrane transport. Predicted to be located in membrane. Expressed in somatic cell. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Is an ortholog of human SLC39A7 (solute carrier family 39 member 7).
Enables cysteine-type endopeptidase activity. Predicted to be involved in autophagy; protein transport; and proteolysis. Predicted to be located in cytoplasm. Expressed in embryonic cell; gonad; and oocyte. Is an ortholog of human ATG4D (autophagy related 4D cysteine peptidase).
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human PPP4C (protein phosphatase 4 catalytic subunit).
Enables cysteine-type endopeptidase activity. Involved in aggrephagy and protein processing. Located in cytoplasm. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; head muscle; and somatic nervous system. Is an ortholog of human ATG4A (autophagy related 4A cysteine peptidase).
Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in several diseases, including Leigh disease; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Is an ortholog of human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2).
Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in ER-associated misfolded protein catabolic process; embryo development; and positive regulation of protein localization to nucleus. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Used to study velocardiofacial syndrome. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Is an ortholog of human UFD1 (ubiquitin recognition factor in ER associated degradation 1).