- hbl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and nematode larval development. Located in nucleus. Expressed in several structures, including body wall musculature; germ line; hypodermis; neurons; and ventral nerve cord.
- T23D8.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Predicted to be located in cytosol and nucleus. Predicted to be part of preribosome, small subunit precursor. Is an ortholog of human LTV1 (LTV1 ribosome biogenesis factor).
- scrm-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be located in plasma membrane. Expressed in body wall musculature and touch receptor neurons. Is an ortholog of several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4).
- nos-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable mRNA binding activity and zinc ion binding activity. Involved in oogenesis and regulation of cell cycle. Located in cytoplasm. Expressed in P0; P4; Z2; and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3).
- lin-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity. Involved in several processes, including egg-laying behavior; mating; and negative regulation of gene expression. Part of polysome. Expressed in several structures, including P5.p hermaphrodite; P7.p hermaphrodite; gonad; neurons; and ventral nerve cord.
- wah-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables enzyme binding activity. Involved in apoptotic DNA fragmentation and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Located in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; X-linked recessive disease (multiple); and dilated cardiomyopathy 1H. Is an ortholog of human AIFM1 (apoptosis inducing factor mitochondria associated 1).
- let-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of gene expression; and regulation of development, heterochronic. Part of RISC complex. Expressed in several structures, including gonad; hypodermis; somatic nervous system; touch receptor neurons; and vulval precursor cell. Used to study cancer.
- sop-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Expressed widely.