- glr-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane.
- glr-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane. Expressed in cholinergic neurons and head neurons. Is an ortholog of human GRIK4 (glutamate ionotropic receptor kainate type subunit 4).
- glr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables enzyme binding activity and ionotropic glutamate receptor activity. Involved in several processes, including forward locomotion; learning or memory; and positive regulation of locomotion. Located in several cellular components, including perinuclear endoplasmic reticulum; postsynapse; and somatodendritic compartment. Part of ionotropic glutamate receptor complex. Expressed in interneuron; neurons; and ventral nerve cord. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; childhood absence epilepsy; and intellectual disability (multiple). Is an ortholog of human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3).
- glr-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane. Expressed in VC neuron and nerve ring neurons. Is an ortholog of human GRIK4 (glutamate ionotropic receptor kainate type subunit 4).
- glr-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ionotropic glutamate receptor activity. Predicted to be involved in ionotropic glutamate receptor signaling pathway and monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Expressed in head neurons and pharyngeal neurons.
- glr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane. Expressed in DVA; M1 neuron; linker cell; nerve ring; and neurons. Human ortholog(s) of this gene implicated in intellectual disability (multiple) and schizophrenia. Is an ortholog of several human genes including GRIA1 (glutamate ionotropic receptor AMPA type subunit 1); GRIA2 (glutamate ionotropic receptor AMPA type subunit 2); and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3).
- egl-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled peptide receptor activity. Involved in negative regulation of egg-laying behavior. Predicted to be located in plasma membrane. Expressed in GLR; nerve ring; and neurons.
- usp-46 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cysteine-type deubiquitinase activity and ionotropic glutamate receptor binding activity. Involved in anterior/posterior axis specification, embryo; positive regulation of gene expression; and positive regulation of locomotion involved in locomotory behavior. Located in endosome and neuronal cell body. Expressed in body wall musculature; intestine; nervous system; pharynx; and vulval muscle. Is an ortholog of human USP46 (ubiquitin specific peptidase 46).
- sol-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables channel regulator activity. Involved in several processes, including hyperosmotic response; positive regulation of glutamatergic synaptic transmission; and thigmotaxis. Located in neuron projection membrane and synapse. Part of ionotropic glutamate receptor complex.