Enables RNA binding activity; enzyme binding activity; and identical protein binding activity. Involved in developmental process involved in reproduction; positive regulation of gene expression; and vulval development. Located in nucleus. Expressed in anchor cell; embryonic cell; excretory cell; germ line; and somatic nervous system.
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO ligase activity. Involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress. Located in metaphase plate. Part of chromatin. Expressed in motor neurons. Is an ortholog of human PIAS1 (protein inhibitor of activated STAT 1); PIAS2 (protein inhibitor of activated STAT 2); and PIAS3 (protein inhibitor of activated STAT 3).
Involved in negative regulation of gene expression; regulation of cell fate specification; and regulation of development, heterochronic. Expressed widely.
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Predicted to be part of NELF complex.