Predicted to enable RNA-dependent RNA polymerase activity. Involved in gamete generation; nuclear pore localization; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in P granule; condensed nuclear chromosome; and metaphase plate. Expressed in germ line.
Involved in positive regulation of Notch signaling pathway and protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Expressed widely. Is an ortholog of human PTPN23 (protein tyrosine phosphatase non-receptor type 23).
Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; essential for integrity and function of EGO; targeted to vacuole via AP-3 pathway; gene exhibits synthetic genetic interaction with MSS4
Predicted to enable RNA-dependent RNA polymerase activity. Is an ortholog of C. elegans ego-1. In C. elegans, ego-1 is involved in gamete generation; nuclear pore localization; and regulatory ncRNA-mediated post-transcriptional gene silencing.
Predicted to enable RNA-dependent RNA polymerase activity. Is an ortholog of C. elegans ego-1. In C. elegans, ego-1 is involved in gamete generation; nuclear pore localization; and regulatory ncRNA-mediated post-transcriptional gene silencing.
Predicted to enable RNA-dependent RNA polymerase activity. Is an ortholog of C. elegans ego-1. In C. elegans, ego-1 is involved in gamete generation; nuclear pore localization; and regulatory ncRNA-mediated post-transcriptional gene silencing.
Enables Notch binding activity. Involved in cellular localization; endosome organization; and regulation of protein catabolic process. Located in basolateral plasma membrane; multivesicular body; and recycling endosome. Expressed in several structures, including vulva. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human PDCD6IP (programmed cell death 6 interacting protein).
Predicted to enable RNA-dependent RNA polymerase activity. Is an ortholog of C. elegans ego-1. In C. elegans, ego-1 is involved in gamete generation; nuclear pore localization; and regulatory ncRNA-mediated post-transcriptional gene silencing.