Predicted to enable actin binding activity and zinc ion binding activity. Involved in several processes, including forward locomotion; muscle cell cellular homeostasis; and sarcomere organization. Located in striated muscle dense body. Part of dystrobrevin complex. Expressed in body wall musculature; head muscle; pharyngeal muscle cell; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in several diseases, including Becker muscular dystrophy; Duchenne muscular dystrophy; cognitive disorder; dilated cardiomyopathy (multiple); and ovarian cancer. Is an ortholog of human DMD (dystrophin) and UTRN (utrophin).
Enables acetylcholine transmembrane transporter activity and cytoskeletal protein binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cholinergic synaptic transmission; and sarcomere organization. Located in plasma membrane. Part of dystrobrevin complex. Expressed in body wall musculature; non-striated muscle; somatic nervous system; and tail neurons. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Is an ortholog of human DTNA (dystrobrevin alpha).
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Located in dendrite; neuromuscular junction; and neuronal cell body. Expressed in several structures, including hypodermal cell; intestine; mechanosensory neurons; spermatheca; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Is an ortholog of human EML2 (EMAP like 2).
Enables cell adhesion molecule binding activity. Located in several cellular components, including cell body; neuron projection; and sarcomere. Expressed in body wall musculature; enteric muscle; neurons; and vulva. Used to study Duchenne muscular dystrophy. Is an ortholog of human SNTG1 (syntrophin gamma 1).
Enables acetylcholine transmembrane transporter activity and calcium channel regulator activity. Involved in several processes, including muscle cell cellular homeostasis; regulation of locomotion; and sarcomere organization. Part of dystrophin-associated glycoprotein complex. Expressed in body wall musculature; neurons; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in long QT syndrome 12 and sudden infant death syndrome. Is an ortholog of human SNTB2 (syntrophin beta 2).