Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in neuron projection; neuronal cell body; and postsynaptic density. Part of Cul3-RING ubiquitin ligase complex. Expressed in command interneuron and intestine. Is an ortholog of human KLHL8 (kelch like family member 8).
Enriched in DA neuron; MC neuron; cephalic sheath cell; and command interneuron based on single-cell RNA-seq studies. Is affected by several genes including daf-16; eat-2; and npr-1 based on RNA-seq studies. Is affected by eight chemicals including rotenone; multi-walled carbon nanotube; and allantoin based on RNA-seq studies.
Enriched in DA neuron; I5 neuron; SAB; VA neuron; and retrovesicular ganglion based on microarray studies. Is affected by clk-1; sir-2.1; and rrf-3 based on microarray studies.
Enables channel regulator activity. Involved in several processes, including hyperosmotic response; positive regulation of glutamatergic synaptic transmission; and thigmotaxis. Located in neuron projection membrane. Part of ionotropic glutamate receptor complex. Expressed in command interneuron; head neurons; and tail neurons.
Enriched in DA neuron; I5 neuron; SAB; VA neuron; and retrovesicular ganglion based on microarray studies. Is affected by eat-2 based on microarray studies. Is affected by Atrazine; cadmium; and fluoranthene based on microarray studies.
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Expressed in BAG; command interneuron; and in male.