Enables several functions, including BH domain binding activity; ion binding activity; and peptidase activator activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of proteolysis; and regulation of apoptotic process. Located in several cellular components, including cytoplasm; membrane; and nucleus. Part of caspase complex. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in Parkinson's disease; lung non-small cell carcinoma; and pancreatic cancer. Is an ortholog of human APAF1 (apoptotic peptidase activating factor 1).
Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process.
Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including establishment of localization; left/right axis specification; and positive regulation of distal tip cell migration. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve.
Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of behavior; positive regulation of embryonic development; and regulation of apoptotic process. Located in cytoplasm. Expressed in several structures, including germ line.
Enables GTPase activator activity and protein sequestering activity. Involved in several processes, including cellular component disassembly; positive regulation of reproductive process; and regulation of cellular component organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and perinuclear region of cytoplasm. Expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; B-cell lymphoma (multiple); colorectal adenocarcinoma; and transient cerebral ischemia. Is an ortholog of human BCL2L2 (BCL2 like 2) and BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough).
Involved in several processes, including actin filament depolymerization; apoptotic process; and positive regulation of cellular component organization. Located in cytosol; mitochondrion; and presynapse. Expressed in several structures, including ABalappaapp; ABaraapapaad; HSN; URX; and proctodeal cell.
Enables cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and identical protein binding activity. Involved in several processes, including apoptotic process; positive regulation of proteolysis; and regulation of developmental process. Located in several cellular components, including mitochondrion; neuronal cell body; and perinuclear region of cytoplasm. Part of caspase complex. Expressed in several structures, including ABaraapapaa; NSM; apoptotic cell; germ line; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); gastrointestinal system cancer (multiple); and prostate disease (multiple). Is an ortholog of human CASP3 (caspase 3); CASP6 (caspase 6); and CASP7 (caspase 7).
Enables protease binding activity and protein homodimerization activity. Involved in several processes, including autophagy of mitochondrion; determination of adult lifespan; and positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis. Located in mitochondrial outer membrane and protein-containing complex. Expressed in body wall musculature; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and perinatal necrotizing enterocolitis. Is an ortholog of human BNIP3 (BCL2 interacting protein 3).
Enables identical protein binding activity and phosphatidylserine binding activity. Involved in engulfment of apoptotic cell. Is spanning component of plasma membrane. Expressed in engulfing cell. Is an ortholog of human JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase).