ced-12

Caenorhabditis elegans

Enables phosphatidylinositol phosphate binding activity; proline-rich region binding activity; and small GTPase binding activity. Involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and left/right axis specification. Located in cytoplasm and plasma membrane. Part of guanyl-nucleotide exchange factor complex. Expressed in intestinal cell and tail. Is an ortholog of human ELMO1 (engulfment and cell motility 1); ELMO2 (engulfment and cell motility 2); and ELMO3 (engulfment and cell motility 3).

elmd-1

Caenorhabditis elegans

Expressed in ciliated neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 88. Is predicted to encode a protein with the following domains: ELMO domain and ELMO/CED-12 family. Is an ortholog of human ELMOD3 (ELMO domain containing 3).

psr-1

Caenorhabditis elegans

Enables identical protein binding activity and phosphatidylserine binding activity. Involved in engulfment of apoptotic cell. Located in plasma membrane. Expressed in engulfing cell. Is an ortholog of human JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase).

ced-7

Caenorhabditis elegans

Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve.

ced-13

Caenorhabditis elegans

Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process.

ced-4

Caenorhabditis elegans

Enables several functions, including ATP binding activity; BH domain binding activity; and peptidase activator activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of synapse pruning; and regulation of apoptotic process. Located in several cellular components, including cytoplasm; membrane; and nucleus. Part of caspase complex. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in Parkinson's disease; lung non-small cell carcinoma; and pancreatic cancer. Is an ortholog of human APAF1 (apoptotic peptidase activating factor 1).

Y75D11A.t2

Caenorhabditis elegans

Is affected by ced-3 based on RNA-seq studies.

ced-9

Caenorhabditis elegans

Enables GTPase activator activity and protein sequestering activity. Involved in several processes, including mitophagy; positive regulation of reproductive process; and regulation of cellular component organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and perinuclear region of cytoplasm. Expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; B-cell lymphoma (multiple); colorectal adenocarcinoma; and transient cerebral ischemia. Is an ortholog of human BCL2L2 (BCL2 like 2) and BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough).

lin-33

Caenorhabditis elegans

Enriched in several structures, including ABalaaaarl; excretory cell; head mesodermal cell; interfacial epithelial cell; and neurons based on microarray; tiling array; RNA-seq; proteomic; and single-cell RNA-seq studies. Is affected by several genes including cyc-1; atfs-1; and csr-1 based on microarray; RNA-seq; and proteomic studies. Is affected by eight chemicals including procyanidin; Sirolimus; and rifampin based on microarray; RNA-seq; and proteomic studies. Is predicted to encode a protein with the following domain: Phosphorylation site.

lin-24

Caenorhabditis elegans

Enriched in several structures, including germ line; germline precursor cell; interfacial epithelial cell; neurons; and pharyngeal muscle cell based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including hsf-1; ppm-1.D; and fog-1 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by five chemicals including Zidovudine; bortezomib; and paraquat based on RNA-seq and microarray studies.