Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including nematode larval development; regulation of locomotion; and reproductive behavior. Located in several cellular components, including adherens junction; cytosol; and nucleus. Expressed in several structures, including gonad; intestine; and vulva.
Predicted to enable actin binding activity and phospholipid binding activity. Involved in cell projection assembly and membrane organization. Located in cytoplasmic side of plasma membrane and filopodium. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Is an ortholog of human MTSS2 (MTSS I-BAR domain containing 2).
Is affected by several genes including daf-16; bar-1; and wdr-5.1 based on microarray and RNA-seq studies. Is affected by allantoin based on microarray studies.
Is affected by several genes including clk-1; aak-2; and bar-1 based on microarray and RNA-seq studies. Is affected by cholesterol based on RNA-seq studies.
Is affected by several genes including pgl-1; bar-1; and glh-1 based on tiling array; microarray; and RNA-seq studies. Is affected by cadmium based on microarray studies.
Enriched in somatic gonad precursor based on RNA-seq studies. Is affected by several genes including bar-1; alg-1; and csr-1 based on tiling array; RNA-seq; and microarray studies.
Is affected by several genes including daf-16; dcr-1; and bar-1 based on microarray studies. Is affected by seven chemicals including Heme; Humic Substances; and copper sulfate based on microarray studies.