- air-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human AURKB (aurora kinase B).
- air-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein serine/threonine kinase activity. Involved in mitotic spindle assembly and positive regulation of protein localization to centrosome. Located in condensed nuclear chromosome and spindle. Expressed in anterior distal tip cell; germ line; and posterior distal tip cell.
- icp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein serine/threonine kinase activator activity. Involved in mitotic cytokinesis and nuclear division. Located in kinetochore and nucleus. Is an ortholog of human INCENP (inner centromere protein).
- spd-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase binding activity. Involved in several processes, including centriole replication; embryo development; and vulval development. Located in centriole; cytoplasm; and pericentriolar material. Expressed in intestinal cell.
- rec-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in double-strand break repair and organelle organization. Located in nuclear lumen and spindle. Part of chromatin. Expressed in Z2; Z3; embryonic cell; and gonad.
- bir-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metal ion binding activity. Involved in several processes, including chromosome organization; egg-laying behavior; and inductive cell migration. Located in condensed chromosome and spindle midzone. Expressed in egg-laying apparatus; hypodermis; pharynx; rectal muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ductal carcinoma in situ; and endometrial hyperplasia. Is an ortholog of human BIRC5 (baculoviral IAP repeat containing 5).
- bmk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable plus-end-directed microtubule motor activity. Involved in negative regulation of mitotic spindle elongation. Located in spindle midzone and spindle pole. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Is an ortholog of human KIF11 (kinesin family member 11).