Bma-aex-6

Brugia malayi

Predicted to enable GTP binding activity and GTPase activity. Is an ortholog of C. elegans aex-6. In C. elegans, aex-6 is involved in exocytosis; positive regulation of defecation; and positive regulation of protein catabolic process.

Bma-aex-5.1

Brugia malayi

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans aex-5. In C. elegans, aex-5 is involved in several processes, including neuropeptide processing; positive regulation of synaptic assembly at neuromuscular junction; and positive regulation of transport.

Bma-aex-5.2

Brugia malayi

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is an ortholog of C. elegans aex-5. In C. elegans, aex-5 is involved in several processes, including neuropeptide processing; positive regulation of synaptic assembly at neuromuscular junction; and positive regulation of transport.

Bma-aex-3

Brugia malayi

Enriched in digestive tract based on proteomic studies. Is predicted to encode a protein with the following domain: MAP kinase-activating death domain protein. Is an ortholog of C. elegans aex-3. In C. elegans, aex-3 is involved in several processes, including mating; oviposition; and positive regulation of transport.

Bm10957

Brugia malayi

Is predicted to encode a protein with the following domains: DENN (AEX-3) domain; cDENN domain; and DENN domain, C-terminal lobe. Is an ortholog of O. volvulus OVOC5188.

Bma-denn-4

Brugia malayi

Is predicted to encode a protein with the following domains: DENN (AEX-3) domain; uDENN domain; dDENN domain; cDENN domain; dDENN domain; uDENN domain; Tetratricopeptide-like helical domain superfamily; and DENN domain, C-terminal lobe. Is an ortholog of C. elegans denn-4.

Bma-pkd-2

Brugia malayi

Is predicted to encode a protein with the following domains: RUN domain; uDENN domain; DENN (AEX-3) domain; PLAT/LH2 domain; dDENN domain; PLAT/LH2 domain; cDENN domain; RUN domain; dDENN domain; uDENN domain; PLAT/LH2 domain superfamily; RUN domain superfamily; and DENN domain, C-terminal lobe. Is an ortholog of C. elegans pkd-2. In C. elegans, pkd-2 is involved in calcium ion transport; response to hermaphrodite contact; and vulval location.

Bma-mtm-5

Brugia malayi

Enriched in reproductive tract based on proteomic studies. Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: GRAM domain; Myotubularin-like phosphatase domain; DENN (AEX-3) domain; uDENN domain; Myotubularin protein; PH domain; cDENN domain; Pleckstrin homology domain; Protein kinase C-like, phorbol ester/diacylglycerol-binding domain; GRAM domain; dDENN domain; uDENN domain; Myotubularin-like, phosphatase domain; PH-like domain superfamily; SBF1/SBF2 domain; Protein-tyrosine phosphatase-like; Myotubularin family; DENN domain, C-terminal lobe; and C1-like domain superfamily. Is an ortholog of C. elegans mtm-5.