encodes, by alternative splicing, three proteins with a COMPASS (CMP) domain and two homeodomains; dve-1
interacts with two or more components of the EGF/RAS signallingpathway, and is required for such signalling in vulval development; the CMP domain is found in the N-terminus of SATB-class CUT homeodomain proteins (e.g. human SATB1), and in Drosophila DEFECTIVE PROVENTRICULUS (DVE), to which DVE-1 may be orthologous; both DVE and dve-1
encode two homeodomains which are highly divergent, but homologous between species, and probably derived by intragenic duplication; dve-1
is required for a normally high rate of growth, fluid excretion, and larval viability in in mass RNAi assays.