Is enriched in AFD; germ line; germline precursor cell; and intestine based on RNA-seq studies. Is affected by several genes including gld-1
; and pgl-1
based on RNA-seq and microarray studies. Is affected by six chemicals including rotenone; Zidovudine; and cadmium based on RNA-seq and microarray studies. Human GTF2H3 exhibits RNA polymerase II general transcription initiation factor activity and protein N-terminus binding activity. Is predicted to encode a protein with the following domains: Transcription factor Tfb4; TFIIH subunit Tfb4/GTF2H3; and von Willebrand factor A-like domain superfamily. Is an ortholog of human GTF2H3 (general transcription factor IIH subunit 3).