Rnf2 [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including RING-like zinc finger domain binding activity; histone H2AK119 ubiquitin ligase activity; and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in response to retinoic acid and spinal cord development. Predicted to be located in nuclear body. Predicted to be part of chromatin and nucleus. Predicted to be active in cytoplasm and nucleus. Biomarker of spina bifida. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
spat-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of gene expression, epigenetic; negative regulation of vulval development; and nematode male tail tip morphogenesis. Predicted to be part of PcG protein complex and ubiquitin ligase complex. Expressed in several structures, including AIYL; AIYR; SMDDL; and SMDDR. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome and pancreatic ductal carcinoma. Is an ortholog of human RING1 (ring finger protein 1) and RNF2 (ring finger protein 2).