Enables PTB domain binding activity; SH2 domain binding activity; and protein kinase binding activity. Involved in several processes, including dauer exit; regulation of developmental process; and regulation of macromolecule metabolic process. Acts upstream of with a negative effect on protein import into nucleus. Located in several cellular components, including cytoplasmic vesicle; neuronal cell body; and plasma membrane bounded cell projection. Expressed in several structures, including XXX cell; gonad; nerve ring; neurons; and vulva. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; glucose metabolism disease (multiple); kidney cancer (multiple); and liver disease (multiple). Is an ortholog of human IGF1R (insulin like growth factor 1 receptor); INSR (insulin receptor); and INSRR (insulin receptor related receptor).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Expressed in pharyngeal muscle cell and rectal epithelium. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).
Enables GTPase activating protein binding activity. Involved in molting cycle. Is an ortholog of human RABEP1 (rabaptin, RAB GTPase binding effector protein 1).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and ovulation. Expressed in spermatheca. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).
Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in dendrite. Expressed in neurons.
Enables identical protein binding activity. Involved in centrosome cycle; positive regulation of mitotic cell cycle, embryonic; and protein localization to organelle. Located in centrosome and cytoplasm.