Enables 5'-3' RNA exonuclease activity. Involved in several processes, including miRNA catabolic process; negative regulation of miRNA-mediated gene silencing; and regulation of vulval development. Located in nucleus. Expressed in M5 neuron; PVT; intestine; and pharyngeal epithelial cell. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; leiomyosarcoma; and lung cancer. Is an ortholog of human XRN2 (5'-3' exoribonuclease 2).
Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Is an ortholog of human BOP1 (BOP1 ribosomal biogenesis factor).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process and leucine catabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).