Enriched in several structures, including AVE; germ line; mechanosensory neurons; rectal epithelial cell; and rectum based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including
daf-16;
daf-2; and
eat-2 based on microarray and RNA-seq studies. Is affected by nine chemicals including aldicarb; rotenone; and Cry5B based on microarray and RNA-seq studies. Human ortholog(s) of this gene implicated in colorectal cancer and developmental and epileptic encephalopathy 54. Human HNRNPU enables several functions, including ATP binding activity; basal RNA polymerase II transcription machinery binding activity; and nucleic acid binding activity. Is predicted to encode a protein with the following domains: B30.2/SPRY domain superfamily; SPRY domain; Concanavalin A-like lectin/glucanase domain superfamily; P-loop containing nucleoside triphosphate hydrolase; and AAA domain. Is an ortholog of human HNRNPU (heterogeneous nuclear ribonucleoprotein U) and HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2).