Predicted to enable histone H3K79 methyltransferase activity. Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Predicted to be located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Is an ortholog of human DOT1L (DOT1 like histone lysine methyltransferase).
Predicted to be located in extracellular space. Is an ortholog of human CLEC18A (C-type lectin domain family 18 member A); CLEC18B (C-type lectin domain family 18 member B); and CLEC18C (C-type lectin domain family 18 member C).
Enables rRNA (cytosine-C5-)-methyltransferase activity and tRNA (cytosine-5-)-methyltransferase activity. Predicted to be involved in rRNA methylation and tRNA methylation. Predicted to be located in mitochondrion. Is an ortholog of human NSUN4 (NOP2/Sun RNA methyltransferase 4).
Involved in maintenance of dauer; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Expressed in several structures, including coelomocyte; gonad; head muscle; nerve ring; and neurons.
Predicted to enable heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to be involved in oxygen transport. Located in endoplasmic reticulum. Expressed in ventral nerve cord.