- act-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in actin cytoskeleton organization and mitotic cytokinesis. Located in striated muscle thin filament. Expressed in body wall musculature; gonad; spermatheca; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta).
- act-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be a structural constituent of cytoskeleton. Involved in cortical actin cytoskeleton organization; embryo development; and mitotic cytokinesis. Located in striated muscle thin filament. Expressed in body wall musculature and gonad. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta).
- act-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity. Involved in several processes, including cortical actin cytoskeleton organization; cytoskeleton-dependent cytokinesis; and embryo development. Located in actin filament and cell cortex. Expressed in body wall musculature; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta).
- lpd-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable rRNA binding activity. Involved in lipid storage. Predicted to be located in membrane. Predicted to be part of preribosome, large subunit precursor. Is an ortholog of human PPAN (peter pan homolog) and PPAN-P2RY11 (PPAN-P2RY11 readthrough).
- act-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in gonad and head. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Human ACTB Contributes to nucleosomal DNA binding activity. Human ACTB enables several functions, including Tat protein binding activity; enzyme binding activity; and kinesin binding activity. A structural constituent of postsynaptic actin cytoskeleton. Is predicted to encode a protein with the following domains: ATPase, nucleotide binding domain; Phosphorylation site; Actin; and Actin family. Is an ortholog of human ACTB (actin beta).
- ppan [Search on AGR]
Rattus norvegicus Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Orthologous to several human genes including PPAN (peter pan homolog); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; amphetamine.
- Actg1l1 [Search on AGR]
Rattus norvegicus A structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in several processes, including actin cytoskeleton organization; protein localization to bicellular tight junction; and regulation of transepithelial transport. Is active in postsynaptic actin cytoskeleton and presynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 2 and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTG1 (actin gamma 1).
- Actg1 [Search on AGR]
Rattus norvegicus A structural constituent of postsynaptic actin cytoskeleton. Involved in response to calcium ion and response to mechanical stimulus. Is active in postsynaptic actin cytoskeleton and presynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 2 and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTG1 (actin gamma 1); PARTICIPATES IN auditory mechanotransduction pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
- Slc18a1 [Search on AGR]
Homo sapiens The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
- Actb [Search on AGR]
Rattus norvegicus Enables protein kinase binding activity. Involved in several processes, including cellular response to electrical stimulus; regulation of norepinephrine uptake; and response to immobilization stress. Located in actin cytoskeleton; axon; and membrane raft. Part of protein-containing complex. Used to study non-alcoholic fatty liver disease. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1. Orthologous to human ACTB (actin beta); PARTICIPATES IN auditory mechanotransduction pathway; INO80 family mediated chromatin remodeling pathway; mitochondria transport pathway; INTERACTS WITH (+)-catechin; (+)-epicatechin-3-O-gallate; (3,4-dihydroxyphenyl)acetic acid.