Enables sequence-specific DNA binding activity. Involved in several processes, including mitotic sister chromatid segregation; negative regulation of transcription by RNA polymerase II; and sex determination. Located in X chromosome and nucleus. Expressed in germ line and oocyte.
Involved in dosage compensation by hypoactivation of X chromosome; meiotic sister chromatid segregation; and mitotic sister chromatid segregation. Located in condensed nuclear chromosome. Part of dosage compensation complex. Expressed widely.
Predicted to enable protein folding chaperone. Predicted to be involved in protein folding. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is an ortholog of human PFDN2 (prefoldin subunit 2).
Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in nuclear chromosome.
Involved in RNA transport and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in apical plasma membrane and cytoplasm. Expressed in ciliated neurons; excretory duct; intestine; and in male.
Predicted to enable nucleotidyltransferase activity. Involved in several processes, including embryo development; meiotic chromosome segregation; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in mutator focus. Expressed in germ line.
Is an ortholog of C. elegans sdc-2. In C. elegans, sdc-2 is involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II.
Predicted to enable RNA-dependent RNA polymerase activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be part of nuclear RNA-directed RNA polymerase complex.
Is an ortholog of C. elegans sdc-2. In C. elegans, sdc-2 is involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II.