- catp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Involved in protein folding. Located in cytoplasmic vesicle and plasma membrane. Expressed in several structures, including egg-laying apparatus; gonad; oocyte; pharynx; and somatic gonad precursor. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is an ortholog of human ATP13A3 (ATPase 13A3).
- YFR035C [Search on AGR]
Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein
- YCR050C [Search on AGR]
Saccharomyces cerevisiae Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
- Snca [Search on AGR]
Homo sapiens Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
- C50B6.7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable alpha-amylase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in extracellular space. Expressed in intestine. Is an ortholog of human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B).
- tps-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity. Predicted to contribute to trehalose-phosphatase activity. Predicted to be involved in trehalose biosynthetic process and trehalose metabolism in response to stress. Predicted to be part of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming). Expressed in CAN; gonad; hypodermis; intestine; and isthmus.
- YDR220C [Search on AGR]
Saccharomyces cerevisiae Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein
- gana-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable alpha-galactosidase activity. Involved in glycoside catabolic process. Located in cytoplasm. Expressed in coelomocyte. Used to study Fabry disease. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schindler disease (multiple); and angiokeratoma. Is an ortholog of human GLA (galactosidase alpha) and NAGA (alpha-N-acetylgalactosaminidase).
- agl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to be involved in glycogen catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Is an ortholog of human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase).