dot-1.2

Caenorhabditis elegans

Predicted to enable histone H3K79 methyltransferase activity. Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Is an ortholog of human DOT1L (DOT1 like histone lysine methyltransferase).