Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Is an ortholog of human IFT74 (intraflagellar transport 74).
Is affected by several genes including daf-12; eat-2; and prg-1 based on tiling array and RNA-seq studies. Is affected by Microcystin-LR and sanguinarine based on microarray and RNA-seq studies.
Predicted to enable chitin binding activity. Involved in endoplasmic reticulum unfolded protein response. Predicted to be located in extracellular region.
Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Expressed in amphid neurons; chemosensory neurons; and phasmid neurons. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Is an ortholog of human IFT81 (intraflagellar transport 81).
Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in nucleolus. Predicted to be part of preribosome, large subunit precursor. Is an ortholog of human WDR74 (WD repeat domain 74).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Expressed in neurons and somatic nervous system.