- Pycard [Search on AGR]
Homo sapiens This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Tyms [Search on AGR]
Homo sapiens Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
- tm [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for a spontaneous mutation exhibit tremors but no convulsions, decrease in serum globulin levels, hyperalbuminemia, infertility, and higher levels of creatine phosphate and ribose in the supernatant fraction of calcium-precipitated trichloracetic acid extracts of the brain. [provided by MGI curators]
- mt-Tm [Search on AGR]
Rattus norvegicus transfer mRNA for Methionine deduced from the genomic sequence of rat mitochondria
- mt-Tm [Search on AGR]
Homo sapiens ASSOCIATED WITH Ataxia; Bilateral cleft lip and palate; Camptodactyly of finger; INTERACTS WITH DDT; dieldrin; valproic acid
- Serinc1 [Search on AGR]
Homo sapiens Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
- Serinc3 [Search on AGR]
Homo sapiens Predicted to enable L-serine transmembrane transporter activity. Involved in defense response to virus; detection of virus; and innate immune response. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]