dhc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable minus-end-directed microtubule motor activity. Involved in several processes, including cellular localization; neuron remodeling; and regulation of cellular localization. Located in several cellular components, including kinetochore; nuclear envelope; and spindle pole. Expressed in germ cell; head; somatic cell; and tail. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; and spinal muscular atrophy with lower extremity predominant 1. Is an ortholog of human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1).