daf-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein tyrosine phosphatase activity. Involved in several processes, including determination of adult lifespan; positive regulation of dauer larval development; and positive regulation of positive chemotaxis. Acts upstream of with a positive effect on protein import into nucleus. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and somatodendritic compartment. Expressed in several structures, including Z2; egg-laying apparatus; germ line; oocyte; and somatic nervous system. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and nervous system cancer (multiple). Is an ortholog of human PTEN (phosphatase and tensin homolog).