- Pedm52 [Search on AGR]
Mus musculus PHENOTYPE: Presumed homozygotes have spina bifida. [provided by MGI curators]
- Skax14 [Search on AGR]
Mus musculus PHENOTYPE: Heterozygous mice exhibit spina bifida and homozygous mice exhibit neural tube defects. [provided by MGI curators]
- m7Anu [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for this mutation exhibit spina bifida and curled tail. [provided by MGI curators]
- m12Bei [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for this ENU-induced mutation exhibit omphalocele, encephalomeningocele, limited spina bifida, and limb defects including oligodactyly. [provided by MGI curators]
- Itpk1 [Search on AGR]
Mus musculus PHENOTYPE: Some mice homozygous for a gene trap allele exhibit neural tube defects (exencephaly and spina bifida), growth retardation, kyphoscoliosis, and rib formation. [provided by MGI curators]
- atx-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cysteine-type deubiquitinase activity. Involved in chemical synaptic transmission. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail neurons. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Is an ortholog of human ATXN3 (ataxin 3) and ATXN3L (ataxin 3 like).
- Mut1170 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a chemically and radiation induced allele exhibit early postimplantation lethality. Mice heterozygous for this allele exhibit very short tails and occasional spina bifida. [provided by MGI curators]
- exo-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-(apurinic or apyrimidinic site) endonuclease activity and phosphoric diester hydrolase activity. Involved in base-excision repair; embryo development; and nematode larval development. Predicted to be located in nucleus. Expressed in hermaphrodite gonad and male gonad. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); prostate carcinoma in situ; and spina bifida. Is an ortholog of human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).
- Cyp26a1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for targeted null mutations die during mid-late gestation and exhibit spina bifida, caudal agenesis, and abnormalities of the kidneys, urogenital tract, hindgut, cervical vertebrae, and rostral hindbrain. [provided by MGI curators]
- gpg2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for this ENU-induced mutation exhibit left-right patterning defects in pulmonary, cardiovascular, and stomach development, partial penetrance of micrognathia, exencephaly, spina bifida, polydactyly, edema, and abnormal eye morphology. [provided by MGI curators]