- hlh-34 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity. Involved in several processes, including neuron fate specification; pharyngeal pumping; and serotonin receptor signaling pathway. Predicted to be located in nucleus. Expressed in ABalapaaap; ABalappapp; AVJL; and AVJR. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); arthritis (multiple); and kidney cancer (multiple). Is an ortholog of several human genes including NPAS1 (neuronal PAS domain protein 1); SIM1 (SIM bHLH transcription factor 1); and SIM2 (SIM bHLH transcription factor 2).
- Sim1 [Search on AGR]
Homo sapiens SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
- cky-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Contributes to sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Expressed in pharyngeal cell. Is an ortholog of human NPAS4 (neuronal PAS domain protein 4).
- Rad18 [Search on AGR]
Saccharomyces cerevisiae E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA
- Npas4 [Search on AGR]
Homo sapiens NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]
- Sim1 [Search on AGR]
Rattus norvegicus Predicted to enable protein heterodimerization activity. Predicted to be involved in ureteric bud development. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1); INTERACTS WITH bisphenol A; gentamycin; paracetamol.
- clec-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in head. Is predicted to encode a protein with the following domains: C-type lectin fold; Spermadhesin, CUB domain superfamily; Lectin C-type domain; CUB domain; C-type lectin-like/link domain superfamily; and C-type lectin-like.