Enables protein serine/threonine kinase activity. Involved in embryo development. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including gonad and tail. Is an ortholog of human SRPK1 (SRSF protein kinase 1); SRPK2 (SRSF protein kinase 2); and SRPK3 (SRSF protein kinase 3).
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans spk-1. In C. elegans, spk-1 is involved in embryo development.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans spk-1. In C. elegans, spk-1 is involved in embryo development.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans spk-1. In C. elegans, spk-1 is involved in embryo development.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans spk-1. In C. elegans, spk-1 is involved in embryo development.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans spk-1. In C. elegans, spk-1 is involved in embryo development.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans spk-1. In C. elegans, spk-1 is involved in embryo development.