This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008]
Enables microtubule binding activity. Involved in several processes, including ciliary body morphogenesis; gonad development; and microtubule bundle formation involved in mitotic spindle midzone assembly. Located in microtubule; mitotic spindle midzone; and nucleus. Is an ortholog of human PRC1 (protein regulator of cytokinesis 1).
Involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development. Located in mitochondrion.
Enables identical protein binding activity. Involved in centrosome cycle; positive regulation of mitotic cell cycle, embryonic; and protein localization to organelle. Located in centrosome and cytoplasm.
Enables protein kinase binding activity. Involved in several processes, including centriole replication; embryo development; and vulval development. Located in centriole; cytoplasm; and pericentriolar material. Expressed in intestinal cell.
Predicted to enable spermidine synthase activity. Predicted to be involved in spermidine biosynthetic process. Predicted to be located in cytosol. Is an ortholog of human SRM (spermidine synthase).
Predicted to enable minus-end-directed microtubule motor activity. Involved in several processes, including cellular localization; neuron remodeling; and regulation of cellular localization. Located in several cellular components, including kinetochore; nuclear envelope; and spindle pole. Expressed in germ cell; head; somatic cell; and tail. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; and spinal muscular atrophy with lower extremity predominant 1. Is an ortholog of human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1).
Is an ortholog of C. elegans spd-3. In C. elegans, spd-3 is involved in several processes, including homologous chromosome segregation; microtubule cytoskeleton organization; and vulval development.