Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1).
Predicted to enable NAD+ binding activity. Is an ortholog of C. elegans sir-2.1. In C. elegans, sir-2.1 is involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage.
Predicted to enable NAD+ binding activity. Is an ortholog of C. elegans sir-2.1. In C. elegans, sir-2.1 is involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage.
Predicted to enable NAD+ binding activity. Is an ortholog of C. elegans sir-2.1. In C. elegans, sir-2.1 is involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage.
Predicted to enable NAD+ binding activity. Is an ortholog of C. elegans sir-2.1. In C. elegans, sir-2.1 is involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage.
Predicted to enable NAD+ binding activity. Is an ortholog of C. elegans sir-2.1. In C. elegans, sir-2.1 is involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage.
Predicted to enable NAD+ binding activity. Is an ortholog of C. elegans sir-2.1. In C. elegans, sir-2.1 is involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage.
Predicted to enable NAD+ binding activity. Is an ortholog of C. elegans sir-2.1. In C. elegans, sir-2.1 is involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage.