Rp1 [Search on AGR]
Homo sapiens This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010]
Rp1 [Search on AGR]
Rattus norvegicus Predicted to enable microtubule binding activity. Predicted to be involved in axoneme assembly; photoreceptor cell development; and photoreceptor cell maintenance. Predicted to act upstream of or within cellular response to light stimulus; positive regulation of non-motile cilium assembly; and retina morphogenesis in camera-type eye. Predicted to be located in several cellular components, including ciliary tip; photoreceptor cell cilium; and photoreceptor inner segment. Predicted to be part of microtubule associated complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 1. Orthologous to human RP1 (RP1 axonemal microtubule associated); PARTICIPATES IN retinitis pigmentosa pathway; INTERACTS WITH aflatoxin B1; bisphenol A; endosulfan.
Mapre2 [Search on AGR]
Homo sapiens The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Stk19 [Search on AGR]
Homo sapiens This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]