daf-16 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables several functions, including 14-3-3 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including defense response to other organism; regulation of dauer larval development; and regulation of gene expression. Located in cytosol and nucleus. Expressed in several structures, including germ cell; gonad; hypodermis; neurons; and somatic cell. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alveolar rhabdomyosarcoma; reproductive organ cancer (multiple); and rheumatoid arthritis. Is an ortholog of human FOXO4 (forkhead box O4).