daf-16 [Browse genome (BioProject PRJNA13758)] [Legacy GBrowse]
Is an ortholog of human FOXO1 (forkhead box O1); FOXO3 (forkhead box O3); and FOXO4 (forkhead box O4). Exhibits several functions, including 14-3-3 protein binding activity; DNA-binding transcription factor activity; and enzyme binding activity. Is involved in several processes, including defense response to other organism; regulation of dauer larval development; and regulation of transcription, DNA-templated. Localizes to the cytosol and nucleus. Is expressed in several structures, including gonad; hypodermis; neurons; rectal gland cell; and ventral nerve cord. Is used to study Parkinson's disease. Human ortholog(s) of this gene are implicated in several diseases, including alveolar rhabdomyosarcoma; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and lens disease (multiple).