lin-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including egg-laying behavior; nematode larval development; and positive regulation of mesodermal cell fate specification. Located in apical plasma membrane and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including body wall muscle cell from M lineage; gonadal sheath cell; somatic nervous system; vulval cell; and vulval precursor cell. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); ductal carcinoma in situ; and hemangioblastoma. Is an ortholog of human NOTCH4 (notch receptor 4).