bub-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables kinetochore binding activity. Involved in several processes, including meiotic cell cycle; positive regulation of nematode male tail tip morphogenesis; and protein localization to kinetochore involved in kinetochore assembly. Located in kinetochore. Expressed in seam cell. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly. Is an ortholog of human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase).