- fcd-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA polymerase binding activity. Involved in nucleotide-excision repair and regulation of DNA-templated DNA replication. Located in nucleus. Expressed in germ line. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group D2; breast cancer; and skin melanoma. Is an ortholog of human FANCD2 (FA complementation group D2).
- Faap24 [Search on AGR]
Homo sapiens FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
- Faap100 [Search on AGR]
Homo sapiens FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 [PubMed 17396147]).[supplied by OMIM, Mar 2008]
- Fancd2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mutant mice exhibit defects observed in human patients with Fanconi anemia (FA) meiotic defects and germ cell loss. In addition, mutant mice display perinatal lethality, susceptiblity ot epithelial cancer, and microphthalmia. [provided by MGI curators]
- PSPHP1 [Search on AGR]
Homo sapiens This gene is significantly upregulated in Fanconi's anemia fibroblasts but downregulated or absent in fibroblasts from normal donors. It is also highly expressed in FA B-cells of complementation group A. [provided by RefSeq, Jul 2008]
- Faap100 [Search on AGR]
Rattus norvegicus Predicted to be involved in protein monoubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of chromatin. Orthologous to human FAAP100 (FA core complex associated protein 100); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
- Faap24 [Search on AGR]
Rattus norvegicus Predicted to enable chromatin binding activity. Predicted to be involved in interstrand cross-link repair. Predicted to be located in nucleoplasm. Predicted to be part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and chromatin. Orthologous to human FAAP24 (FA core complex associated protein 24); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
- Fance [Search on AGR]
Rattus norvegicus Predicted to be involved in protein monoubiquitination. Predicted to be located in centrosome; chromosome; and nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex and chromatin. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group E. Orthologous to human FANCE (FA complementation group E); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
- Ppa-ptp-1 [Browse genome (BioProject PRJNA12644)] [Search on AGR]
Pristionchus pacificus Is predicted to encode a protein with the following domains: PH-like domain superfamily; FERM C-terminal PH-like domain; FERM, C-terminal PH-like domain; FERM, N-terminal; FERM N-terminal domain; FERM central domain; FERM adjacent (FA); FERM superfamily, second domain; FERM/acyl-CoA-binding protein superfamily; Ubiquitin-like domain superfamily; and Band 4.1 domain. Is an ortholog of C. elegans C33F10.8.
- Usp1 [Search on AGR]
Homo sapiens This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]