Enables calcium ion binding activity. Located in basement membrane and extracellular space. Expressed in body wall musculature; gonad; head; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); osteogenesis imperfecta type 17; and progressive osseous heteroplasia. Is an ortholog of human SPARC (secreted protein acidic and cysteine rich).
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]