Is affected by several genes including daf-2; hsf-1; and eat-2 based on tiling array; RNA-seq; and microarray studies. Is affected by four chemicals including cadmium; fluoranthene; and Chlorpyrifos based on microarray studies.
Predicted to be located in extracellular region. Expressed in coelomocyte; neurons; and pseudocoelom. Used to study frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; and multiple sclerosis (multiple). Is an ortholog of human GRN (granulin precursor).