Involved in regulation of gene expression. Located in nucleus. Part of PcG protein complex and nucleosome. Expressed in several structures, including Caa; Psub4; Z2; Z3; and germ line.
Is affected by several genes including eat-2; eri-1; and mes-3 based on RNA-seq and microarray studies. Is affected by adsorbable organic bromine compound; Sirolimus; and allantoin based on microarray studies.
Predicted to contribute to nucleosome binding activity. Involved in regulation of gene expression. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; intestinal cell; and oocyte. Is an ortholog of human EED (embryonic ectoderm development).
Enables histone H3K27 methyltransferase activity. Involved in epigenetic regulation of gene expression; germ-line stem cell division; and tissue development. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) and EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).