Enables JUN kinase kinase activity and SH2 domain binding activity. Involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade. Predicted to be located in cytoplasm. Expressed in several structures, including ganglia; hermaphrodite gonad; intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K7 (mitogen-activated protein kinase kinase 7).
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans mek-1. In C. elegans, mek-1 is involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade.