Is predicted to enable transcription coregulator activity. Is involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of vulval development. Located in nucleus. Is expressed in several structures, including hypodermal cell; intestine; pharynx; and vulva. Human ortholog(s) of this gene are implicated in FG syndrome and Ohdo syndrome. Is an ortholog of human MED12L (mediator complex subunit 12L).
Is affected by several genes including daf-16; sir-2.1; and mdt-15 based on microarray and tiling array studies. Is affected by resveratrol; tetrabromobisphenol A; and dafa#1 based on microarray studies.
Enables nuclear hormone receptor binding activity and transcription coactivator activity. Is involved in several processes, including determination of adult lifespan; nematode larval development; and sequestering of triglyceride. Is expressed in head. Is used to study chromosome 22q11.2 deletion syndrome, distal. Is an ortholog of human MED15 (mediator complex subunit 15).